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| References
- Testosterone, the brain and psyche |
6.
Seidman SN,.Walsh BT. Testosterone and depression
in aging men. Am.J.Geriatr.Psychiatry 1999;7:18-33.
Abstract: In men, testosterone secretion affects neurobehavioral
functions such as sexual arousal, aggression, emotional
tone, and cognition. Beginning at approximately age
50, men secrete progressively lower amounts of testosterone;
about 20% of men over age 60 have lower-than-normal
levels. The psychiatric sequelae are poorly understood,
yet there is evidence of an association with depressive
symptoms. The authors reviewed 1) the physiology of
the hypothalamic-pituitary-gonadal axis and its changes
with age in men; and 2) the evidence linking testosterone
level and major depression in men. Data on this relationship
are derived from two types of studies: observational
studies comparing testosterone levels and secretory
patterns in depressed and non-depressed men, and treatment
studies using exogenous androgens for male depression.
The data suggest that some depressed older men may
have state-dependent low testosterone levels and that
some depressed men may improve with androgen treatment |
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