References - Vasectomy
1. Mullooly JP, Wiest WM, Alexander NJ, Greenlick MR, Fulgham DL. Vasectomy, serum assays, and coronary heart disease symptoms and risk factors. J Clin.Epidemiol. 1993;46:101-109.
Abstract: We compared three serum assays (two antisperm antibody assays and one assay for circulating immune complexes) and a number of CHD-related variables in 69 vasectomized (V) and 126 non-vasectomized (NV) participants in the Portland Center for the Multiple Risk Factor Intervention Trial. Significant differences between the V and NV men were found in sperm agglutination (SA) and sperm immobilization (SI) titers, as well as in several CHD risk factors, symptoms, and treatments; men in the V group had higher titers for SA and SI, smoked more, and had lower diastolic and systolic blood pressure than men in the NV group. Differences between V and NV in SA and SI activity remained even after we controlled for any effects that CHD risk factors, symptoms, and treatments may have had on the serum assays. Antibody development tended to decrease with age-at-vasectomy and increase with time-post-vasectomy. In the case of SA the antibodies clearly increased with time-post-vasectomy.
Notes:
Vasectomised patients developed anti-sperm antibodies which increased with time, especially when when the operation was performed when young. This is important when vasectomy is performed in men even in their twenties. The association with CHD risk factors is interesting and deserves much more attention than it has received. One of the authors, Nancy Alexander has done much good work over twenty years on Vasectomy and CHD.

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