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| References
- Vasectomy |
2.
Alexander NJ, Fulgham DL, Plunkett ER, Witkin
SS. Antisperm antibodies and circulating immune complexes
of vasectomized men with and without coronary events.
Am J Reprod Immunol Microbiol. 1986;12:38-44.
Abstract: We compared antisperm antibody and
circulating immune complex (CIC) levels in serum samples
from 101 vasectomized and 101 normal age-matched nonvasectomized
men; 31 of each group had histories of coronary heart
disease (CHD). Vasectomy and CHD status were treated
as categorical independent variables in the two-way
analysis of variance. Elevations of both systolic
and diastolic blood pressures were significantly associated
with age and body mass index but not vasectomy. Antisperm
antibodies (immobilizing and agglutinating) were significantly
associated with vasectomy (P less than or equal to
.001); the incidences were similar in men with and
without CHD. The CICs were significantly associated
with vasectomy in a Staphylococcus aureus (FcSa) CIC
assay (P less than or equal to .001) and a Raji cell
CIC assay (P less than or equal to .05). A third CIC
assay, the Clq binding assay, did not reveal a difference
between any subgroups. Generally, CICs occurred more
frequently in the CHD group by the FcSa assay and
particularly the Raji cell assay (P less than or equal
to .001). In summary, vasectomized men had a higher
incidence and higher levels of circulating antisperm
autoantibodies and CICs than did age-matched controls.
Notes: Higher CIC's (Circulating Immune Complexes)
cannot be good news in relation to CHD, especially
in view of recent work on possible bacterial contribution
to the disease. |
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